We may be at the beginning of a revolution in how we treat cancer.
For years, doctors have treated patients using a combination of chemotherapy, radiation, and surgery to try and stifle the disease.
But in the past few years, doctors have started using a promising tool: immunotherapy.
Unlike chemotherapy, which involves administering powerful drugs that kill both cancerous and healthy cells (most healthy cells can repair themselves), immunotherapies harness the power of the immune system to help it identify and knock out just the cancerous cells.
Recently, former President Jimmy Carter revealed he had tested cancer free just a few months after initially sharing that he’d been diagnosed with metastatic (meaning it’s spread from its primary spot) melanoma that had spread to his brain. Carter had used a combination of radiation therapy and Keytruda, one of these new immunotherapy drugs, which was delivered intravenously once every three weeks.
In cancer patients, a type of protein called PD-1 stop the immune system from doing its job and fighting the cancerous cells. Keytruda gets in the way of those dysfunctional proteins, allowing the immune system to access the cancer cells. Then, with the help of the radiation therapy to shrink tumours, it can help knock out the cancer in some people.
The incredible success of the drug in Carter’s case brought the treatment into the spotlight, but the attention appears to have been a long time coming.
More than a century in the works
Recent immunotherapy successes are far from the first time researchers have explored using the immune system to fight cancer.
As NPR noted, in the 1890s a doctor named William Coley treated his cancer patients by infecting them with bacteria. The treatment worked for some of them — with the immune system on full force to knock out the invading bacteria, the immune system could also take on the cancerous cells and kill them on the way, which wouldn’t necessarily happen if the immune system wasn’t stimulated.
At the time, very little was understood about the immune system, and after Coley died, his methods stopped being used in favour of radiation therapy. But in 1953, Coley’s daughter Helen Coley Nauts founded the Cancer Research Institute, which works to understand the relationship between cancer and the immune system.
In the 1970s, scientists pursued an immunotherapy using a protein called tumour necrosis factor, or TNF, which the body makes in response to foreign organisms in the body, including bacteria and tumour cells.
Jan Vilcek, a microbiology professor at New York University and one of the scientists who worked on developing a TNF treatment at the time, told Business Insider that in animal testing, TNF was able to block the growth of tumours. But when put into humans, the added TNF was so toxic that it made people sick, even at doses that wouldn’t kill tumours.
That was the end of immuno-oncology research for a while (though not the end of the story for TNF-related therapies).
Even so, the Cancer Research Institute stuck with it, and eventually in 2011, the first immunotherapy was approved in the US to treat melanoma. The drug, called Yervoy or ipilimumab, helps the immune system respond to cancerous cells by keeping it from pushing on the brakes before it has a chance to kill the cells. Since then, a number of other cancer treatments using the immune system have been approved, with more still in development.
“For us, the excitement that we’re now seeing in the clinic is phenomenal,” Cancer Research Institute CEO Jill O’Donnell-Tormey told Business Insider. “It’s very validating for us.”
Vilcek too is optimistic about the state of immunotherapies to treat cancer.
“I think it’s really very very encouraging and in certain types of cancer, it’s making a huge difference,” Vilcek said.
In the middle of a cancer treatment revolution
Immunotherapies are working incredibly well for some cancers, such as melanoma, lung cancer, head and neck cancer, and multiple myeloma.
Yet for others, there’s still a lot to learn.
“We’re a long way from knowing the full story,” said O’Donnell-Tormey. For example, while Keytruda, the drug Carter used, has worked “dramatically well,” it still doesn’t have a success rate on its own that’s anywhere close to 100% for the type of cancer it targets. “We need to understand why someone like Jimmy Carter responding.”
In fact, roughly 30% of metastatic melanoma patients using Keytruda alone respond completely. That’s still better than the average response rate of chemotherapy treatments on their own in cases of metastatic melanoma. When the drug is combined with others, that success rate goes up, which also holds true for other medications like chemotherapy. But for those who still don’t respond at all, that’s the challenge. And combining different medications and therapies might be the answer.
This year was a good one for immunotherapies: In October, Keytruda was also approved to treat a form of lung cancer. It moved forward in getting developed to treat a wide variety of other cancer types as well.
In the last year, Opdivo, another drug that targets the PD-1 protein like Keytruda and was originally approved to treat patients with certain types of melanoma, was also approved to treat forms of lung cancer and kidney cancer.
In blood cancer treatment, 2015 saw the approvals of more than one multiple myeloma immunotherapy. Others went so far as to get approval for a genetically modified herpes virus t
hat’s programmed to kill tumour cells in patients with melanoma that recurs after surgery (making history as the first cancer viral therapy).
Investors expect new cancer immunotherapies to make billions of dollars in sales in the next couple of years.
So stay tuned — more treatments are ahead.
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