A new protein discovered in tardigrades — or water bears if you want to use their cuter name — helps shield them from harmful radiation, making them virtually indestructible. And researchers hope their new finding could be used to protect the DNA in our cells too.
Scientists from the University of Tokyo decoded the water bear’s genome to find the protective protein.
Like water bear cells, human cells are damaged when they’re exposed to X-rays. But in the lab, when the scientists manipulated human cells to be able to create the water bear shielding protein — called Dsup — they showed about half the DNA damage as normal cells.
This changes a lot of what scientists thought they knew about how water bears deal with radiation, as they were previously thought to have proteins that repaired damaged DNA, rather than proteins that halt damage altogether.
“What’s astonishing is that previously, molecules that repair damaged DNA were thought to be important for tolerating radiation. On the contrary, Dsup works to minimise the harm inflicted on the DNA,” Takuma Hashimoto, one of the lead authors of the paper, said in a statement.
Water bears have fascinated researchers for a long time.
There are over 1,000 species of water bears. The creatures grow to about 0.5mm long and get their name from their bear-like claws and podgy frame. If you want to find some, pick some wet moss and squeeze it, and water bears should fall out, which you’ll be able to see through a microscope.
It is widely known that these critters can withstand some remarkably tough conditions. By shrivelling up into dehydrated balls, water bears can survive boiling and absolute zero temperatures, and can live without food or water for over 30 years. They have even survived in the vacuum of space.
They manage this by going into a state of cryptobiosis, which is when all metabolic processes stop. When they find themselves in better conditions, they come out of the state and carry on as they did before. Also found in the water bear genome were more copies of an anti-oxidant enzyme and a DNA repair gene than in any other animal. These help counteract oxidation damage when it’s dehydrated.
The discovery of the new radiation shielding protein reveals another trick these tough animals have up their sleeve. By discovering more about their survival tricks, the researchers hope to learn more ways to protect human cells from damage. For example, if dehydration tolerance can be transferred, this could be particularly useful when transporting delicate skin grafts and organs.
There’s also the possibility of learning about what kind of organisms could live in extremely hostile environments — such as on the surface of Mars — and maybe even bioengineering organisms to survive there.
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