One of the most attention-catching biotech deals of the year slotted into place after a fateful July meeting that didn’t directly have to do with either company, a new filing shows.
In August, Gilead Sciences said it would spend $US12 billion ($AU15 billion) to acquire Kite Pharma, a cancer drugmaker that has no approved therapies yet.
The decision came a few months ahead of Kite’s possible approval for a highly personalised cancer treatments called CAR T-cell therapy. It’s a form of cancer immunotherapy — or a therapy that harnesses the body’s immune system to take on cancer cells.
According to an SEC filing from Kite, representatives from Kite and Gilead had been meeting as far back as 2015. But the deal accelerated after a key meeting in July involving an FDA panel and a similar treatment from Novartis. Here’s how it played out:
- Gilead and Kite had been having “informal discussions” for two years.
- Then, in January, the Gilead senior vice president of corporate development, Andrew Dickinson, and executive vice president for business development, Helen Kim, met informally with Kite execs at an industry conference. They “generally discussed Gilead’s interest in the oncology field and potentially learning more about the Company.”
- Gilead and Kite entered into a confidentiality agreement around February 10 to “facilitate such further discussions.”
- Later the same month, Kite released data that found that out of 101 patients, 36% had a complete response to the treatment after six months.
- Conversations continued with executives regularly meeting. On July 6, Kite CEO and chairman Dr. Arie Belldegrun reached out to advisory firm Centerview Partners to discuss the interactions Kite and Gilead had been having.
- On July 12, Kymriah, a treatment made by Novartis to treat pediatric acute lymphoblastic leukemia, received a key recommendation from an FDA panel at an advisory committee meeting. “I think this is most exciting thing I’ve seen in my lifetime,” Dr. Tim Cripe, an oncologist who was on the panel said while explaining his vote.
- That’s about the same time the Kite-Gilead deal started heating up. On July 13, Kite executives met with Gilead’s executive chairman John C. Martin to talk about the drugmaker’s pipeline and its CAR-T therapy.
- By July 16, Gilead made its first offer to buy the company, starting with an offer of $US127 per share. After Kite turned down two offers, the company agreed to be acquired for $US180 per share, or $US11.9 billion.
- Two days after Gilead and Kite announced the deal, the Food and Drug Administration approved Kymriah.
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