Scattered among at least three different efforts to primary Sinema in Arizona are several notable Sanders supporters and campaign veterans.
The vote is a major setback for President Biden's domestic agenda and for congressional Democrats, who failed to unify on the filibuster.
The vote was a major setback for Senate Democratic leaders, who now face a difficult uphill battle to change the chamber's filibuster rules.
Gallego, a Marine turned Arizona congressman has not shied away from criticizing Sinema in recent weeks for her stances on the filibuster. His backers say he's the best Democrat to replace her.
The statement comes after Sinema doubled down on her opposition to overhauling the filibuster, effectively killing Biden's push for voting rights legislation.
"If you can deliver an infrastructure bill for bridges, you can deliver voting rights for Americans," said Martin Luther King III at a protest in DC.
Grassroots groups in Arizona are working feverishly to find someone to challenge and unseat Democrat Kyrsten Sinema over her blockage of Biden's agenda and objection to nixing the filibuster. They saw a fundraising boost after her floor speech.
Congressional Democrats used a creative procedural workaround to fast-track consideration of the bills — but they still face long odds in the Senate.
Biden on Tuesday endorsed changes to the filibuster rules if voting rights bills continue to be blocked. Obama said he supports Biden's call.
"I have known, liked, and personally respected Joe Biden for many years. I did not recognize the man at that podium yesterday," McConnell said.
"Voting rights now is a partisan thing," Jeffries said, criticizing Republicans for being "largely allergic to the notion of 'one person, one vote.'"
"I think he listens to everybody, which is the problem. Whoever he's heard from most recently has the upper hand," one source told Axios.
Kaine was among hundreds of motorists trapped on Virginia's I-95 for over a day after a winter storm led to dangerous road conditions.
"I won't let the perfect be the enemy of the good," Murphy said as he spoke of the realities of Senate rules in passing gun-control bills.
"If Mitch McConnell were in their shoes, what would he do? Given what we know, would we see him letting the filibuster stand?" Acosta said on Saturday.
Some Senate Republicans broke with Trump to help Democrats clear a procedural vote paving the way for final passage.
It wasn't immediately clear if Manchin and Sinema would be swayed by the threat of economic catastrophe to abandon their attachment to the filibuster.